Sunday, November 19, 2006

Coagulent

BALTIMORE (AP) — A blood-coagulating drug designed to treat rare forms of hemophilia is being used on critically wounded U.S. troops in Iraq despite evidence it can cause clots that lead to strokes, heart attacks and death in other patients, The (Baltimore) Sun reported for Sunday's editions.
Recombinant Activated Factor VII, which is made by Danish pharmaceutical company Novo Nordisk, is approved in the United States for treating forms of hemophilia that affect fewer than 3,000 Americans. It costs $6,000 a dose.
The Food and Drug Administration said in a warning last December that giving Factor VII to patients who don't have the blood disorder could cause strokes and heart attacks. Its researchers published a study in January blaming 43 deaths on clots that developed after injections of Factor VII.
However, the Army medical command considers it a medical breakthrough that gives front-line physicians a way to control deadly bleeding. Physicians in Iraq have injected it into more than 1,000 patients, reported The Sun, which makes its first Sunday edition available Saturday afternoon.
"When it works, it's amazing," said Col. John B. Holcomb, an Army trauma surgeon and commander of the Army's Institute of Surgical Research. "It's one of the most useful new tools we have."
Critics strongly disagree.
"It's a completely irresponsible and inappropriate use of a very, very dangerous drug," said Dr. Jawed Fareed, director of the hemostasis and thrombosis research program at Loyola University in Chicago and a specialist in blood-clotting and blood-thinning medications.
Military doctors said patients requiring transfusions of 10 or more units of blood have a 25 percent to 50 percent chance of dying from their injuries, and there is enough evidence of the drug's effectiveness to continue promoting its use.
"I've seen it with my own eyes," said Air Force Lt. Col. Jeffrey Bailey, a trauma surgeon deployed this summer as senior physician at the American military hospital in Balad, Iraq. "Patients who are hemorrhaging to death, they get the drug and it stops. Factor VII saves their lives."
However, doctors at military hospitals in Germany and the United States have reported unusual and sometimes fatal blood clots in soldiers evacuated from Iraq, including unexplained strokes, heart attacks and pulmonary embolisms, or blood clots in the lungs. And some have begun to suspect Factor VII, The Sun reported.
Contacted Saturday by The Associated Press, an Army spokeswoman, Mary Ann Hodges, declined to comment immediately on the report because she had not seen it.
Doctors say determining the precise cause of blood clots is rarely possible, making it difficult to establish definitively whether Factor VII is responsible for complications. And military doctors caution against drawing any conclusions from individual cases.
Officials at Novo Nordisk said complications don't mean the drug is too dangerous to use.
"It's really not a question of an absolute safety level, but rather a ratio of benefit to risk that has to be established," said Dr. Michael Shalmi, vice president of biopharmaceuticals for Novo Nordisk.
"We're making decisions, in the middle of a war, with the best information we have available to us," said Holcomb at the Army's Institute of Surgical Research.

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Thursday, October 12, 2006

fraud at the EPA

Kate RaifordPublished: Tuesday October 10, 2006
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Increasing fraud and other misconduct at Environmental Protection Agency water quality analysis labs has put all of us at risk for contaminants and disease outbreaks, RAW STORY has learned. However, since the scope and risk cannot be measured, EPA is downplaying the findings.
A Sept. 21 report issued by the EPA Office of Inspector General (OIG) found hundreds of weaknesses—missing data, no log books, falsified measurements—not noted by EPA. The office had found many of the same problems in 1999, and they were identified again by EPA in 2002. EPA did nothing, the report said.
Drinking water and wastewater fraud investigations comprise more than half of all OIG investigations.
“Fraud in even just one lab can have a significant impact on several thousands, millions of people,” said a spokesman for the EPA OIG. “We think this is an area vulnerable and susceptible to fraud.”
In a response to the report, EPA said in a statement that “[g]iven that the report includes recommendations that would require significant investments on the part of EPA and states, it is also critical to demonstrate more specific evidence of the problem.”
Speaking to RAW STORY, an analytical chemist and former lab inspector described some of the types of fraud and questionable lab practices he’s observed.
For example, states routinely send out test samples that must be analyzed by all labs. The test samples are all the same, and labs will call each other to check answers. “What then followed were phone calls between the labs trying to find out what the results were that other people had gotten, like high school kids with a take home test,” the chemist said in an e-mail.
“Now this alone isn’t out-and-out fraud, because the labs still presumably analyze the samples,” he wrote, “but if someone is expecting the answer to be seven, they’re going to keep testing the sample trying to get seven to turn in for certification, even if seven isn’t really the right answer.”
Two other types of fraud are called “time travel” and “mountain ranging,” and both involve manipulating equipment to make it look like the experimental protocol was followed or the correct result was produced. EPA OIG found evidence of both, according to its report, along with “suspicious condition[s] or practice[s],” such as altered signatures on reports, no maintenance records on instruments, and numerous quality control failures.
The scope of the problem is hard to measure. Lab inspectors in some regions do not look for fraud. EPA OIG has not done national or statewide checks on lab misconduct to measure the extent of fraud or the likelihood of danger to people, the report said.
In Arizona, where state inspectors use a more advanced analysis than EPA requires, inspectors have found more cases of fraud than any other state. About one in seven labs there had fraudulent or severely inappropriate lab procedures.
One consequence of fraud might be outbreaks of waterborne diseases. No cases have been tied to fraud, but this is because outbreaks are never traced all the way back to lab procedures and notes, the report said. However, his is the reason given by EPA in the report for its reluctance to follow all of OIG’s 10-point recommendation plan—that because fraud has never been tied to any cases of disease, it doesn’t justify all the protective measures.
EPA Office of Ground Water and Drinking Water declined to comment and cited the report for its statement. “[W]e are concerned that the report does not adequately distinguish between possibilities and likelihoods and, in not doing so, may present an unnecessarily alarming picture to the American public,” Benjamin H. Grumbles said in the report. He is the assistant administrator to the Office of Water.
So how prevalent is fraud? The lab inspector RAW STORY spoke with said fraud is seldom looked for because it is perceived as rare.
“Of course that becomes a self-fulfilling prophecy—if you don’t look, you never find,” he said. “I think some of the sense of frustration that comes out in the [O]IG report regarding EPA’s relative inaction compared to what the [O]IG recommends has basis here. It’s a cultural mindset that makes it not a priority.”
“The fact that it may also be expensive and difficult to root out doesn’t encourage EPA management to follow up on it either, given the many issues EPA has to address, why take on a hard problem that’s costly to address and whose scope, as the [O]IG noted, isn’t fully known.”
But fraud is preventable and detectable. A good lab inspector will interview lab employees while they are working, look at data, inspect instruments and observe how the lab is operating, said Wisconsin State Certification Officer and audit chemist Alfredo Sotomayor. He served on the EPA OIG’s expert panel to review the drinking water analysis process.
Sotomayor added that inappropriate lab procedures are often the product of rushed work, pressure to cut costs, lack of oversight and inefficiently trained employees, saying, “The amount of money for analysis is decreasing. [There’s an] increasing pressure to cut costs.”
EPA has until Dec. 21 to respond to the report with a plan of action.

Tuesday, October 10, 2006

Doctors

Four top doctors arrested over illegal human experimentation
By Ran Reznik, Haaretz Correspondent
Four senior doctors at Kaplan Hospital in Rehovot and Hartzfeld Geriatric Hospital in Gedera suspected of illegally experimenting on humans were arrested Monday.The national fraud squad has opened an investigation into the affair. The four are suspected of abuse, aggravated assault, causing death through negligence, fraud, forgery, breach of statutory duty, and disruption of legal proceedings.The Tel Aviv Magistrate's Court on Monday extended by three days the remands of Kaplan-Hartzfeld deputy director Dr. Shmuel Levi and Dr. Nadia Kagensky. The third suspect, Dr. Alona Smirnov, was released to house arrest for five days, and the fourth suspect was released following an investigation.

Police searched the houses of all four suspects and confiscated incriminating documents.Many of the details of the affair were revealed in a series of Haaretz articles on the subject, as well as Channel 2 TV's investigative documentary series "Fact."In May 2005, the State Comptroller's Office slammed the hospitals over the illegal experimentation in a report. According to a report issued by the investigations department of the Health Ministry and exposed by Haaretz, the hospitals in Gedera and Rehovot conducted illegal and unethical testing on thousands of elderly patients for years. During one of the incidents described, twelve patients died either during the experiments or shortly after they took place, but these incidents were not reported to the Health Ministry or investigated, as is required by law. The Health Ministry's director general filed a complaint with police following an internal inquiry into the affair and the fraud squad confiscated from the hospitals many documents pertaining to the experimentation. The ministry's investigation revealed that some of the patients were included in the experiments without providing their consent, while some of them suffered from severe mental damage, which prevented them from being legally capable of providing consent. According to the report, some of the tests did not even yield any medically or scientifically beneficial results. Furthermore, some of the experiments were conducted despite top doctors' warnings that they were illegal or unethical. The report voices harsh criticism of the Helsinki committee at the hospitals, responsible for approving the experiments and failing to protect the public's best interests. The ministry's report further condemns the hospital's management for failing to address the complaints and information handed to it over the past few years, describing the flawed medical procedures. According to the report, some doctors received promotions, both in their professional and academic careers, on the basis of the illegal tests. In some cases, the tests were used as the basis for research studies published in local and international medical journals. At least four doctors at the hospitals were named as experts in Geriatrics based on the illegal tests they allegedly conducted along with their colleagues.

Sunday, September 03, 2006

obesity

By ROHAN SULLIVAN, Associated Press Writer 11 minutes ago
SYDNEY, Australia - An obesity pandemic threatens to overwhelm health systems around the globe with illnesses such as diabetes and heart disease, experts at an international conference warned Sunday.

"This insidious, creeping pandemic of obesity is now engulfing the entire world," Paul Zimmet, chairman of the meeting of more than 2,500 experts and health officials, said in a speech opening the weeklong International Congress on Obesity. "It's as big a threat as global warming and bird flu."
The
World Health Organization' name=c1> SEARCHNews News Photos Images Web' name=c3> World Health Organization says more than 1 billion adults are overweight and 300 million of them are obese, putting them at much higher risk of diabetes, heart problems, high blood pressure, stroke and some forms of cancer.
Zimmet, a diabetes expert at Australia's Monash University, said there are now more overweight people in the world than the undernourished, who number about 600 million.
People in wealthy countries lead in overeating and not doing enough physical activity, but those in the poorer nations of Asia, Africa and Latin America are quickly learning bad habits, experts said.
Thailand's Public Health Ministry, for instance, announced Sunday that nearly one in three Thais over age 35 is at risk of obesity-related diseases.
"We are not dealing with a scientific or medical problem. We're dealing with an enormous economic problem that, it is already accepted, is going to overwhelm every medical system in the world," said Dr. Philip James, the British chairman of the International Obesity Task Force.
The task force is a section of the International Association for the Study of Obesity, a professional organization of scientists and health workers in some 50 countries that deal with the issue.
James said the cost of treating obesity-related health problems was immeasurable on a global scale, but the group estimated it at billions of dollars a year in countries such as Australia, Britain and the United States.
Among the most worrying problems are skyrocketing rates of obesity among children, which make them much more prone to chronic diseases as they grow older and could shave years off their lives, experts said.
The children in this generation may be the first in history to die before their parents because of health problems related to weight, Kate Steinbeck, an expert in children's health at Sydney's Royal Prince Alfred Hospital, said in a statement.
Experts at the conference said governments should impose bans on junk food advertising aimed directly at children, although they acknowledged such restrictions were unlikely to come about soon because the food industry would lobby hard against them.
"There is going to be a political bun fight over this for some time, but of course we shouldn't advertise junk food to children that makes them fat," said Dr. Boyd Swinburn, a member of the International Obesity Task Force.
Dr. Claude Bouchard, president of the International Association for the Study of Obesity, an umbrella group for medical organizations dealing with weight-related and children's health issues, said the group supported advertising bans as official policy.
But the policy position is unlikely to have any immediate effect on influencing governments to introduce such bans, said Bouchard, head of the Pennington Research Center at Louisiana State University at Baton Rouge.

Saturday, September 02, 2006

PETA Stuff

St. Louis Post-Dispatch6/21/2003 Animal rights spy infiltrates Missouri labBy Todd C. Frankel Post-DispatchHATTON, Mo. — They never suspected she was a spy. She was just another research associate at theSinclair Research Center animal laboratory in thistiny town outside Columbia, working with the hundredsof dogs, cats, sheep and pigs used in experiments fordifferent companies. She was in her late 20s and certainly friendly, herformer co-workers recalled. She had straight brownhair with red highlights. She often took lunch at herdesk, eating Ramen noodles or salad. She liked to talkabout her two dogs. She once mentioned her father wasa dentist, and she had the good teeth to prove it. But like the tiny video camera she hid on her body,there was more to her than she let on. She was workingundercover for the animal activist group People forthe Ethical Treatment of Animals. Her mission:document any mistreatment of animals. For nine months, her deception — a possible violationof state law — continued. Then one day in February,she abruptly quit her job and disappeared. A month later, her work surfaced as the backbone forPETA's launch of a negative publicity campaign againstSinclair and several of its clients, including petfood giant Iams, St. Louis-based Nestle Purina Petcareand St. Louis biotech firm Isto Technologies. PETA hassplashed allegations on its Web site, called newsconferences and complained to federal regulators toend what it calls a "hidden world of cruelty," whereit claims terrified animals are confined to smallcages for dubious research. But figuring out what to believe is not so simple. Thepast several months has seen the renewal of along-standing battle between two sworn enemies: PETAand companies that use animals for research. As theFoundation for Biomedical Research's Frankie Trull,who has watched the fight for years, said, "With PETA,there is no middle ground." The campaign has made an impact. Sinclair, whichdenies there was systemic animal abuse while admittingthere were problems, has already lost clients. Fortypercent of its staff has been laid off. But GuyBouchard, who owns and runs the center, said what hashurt the most is "the highest level of betrayal" byhis former employee. "No one survives when someone comes into your house todestroy you," Bouchard said. "I've done well all mylife helping people and animals. Now this." Birth of a PETA spy PETA's undercover investigators rarely talk abouttheir exploits. The woman who infiltrated Sinclairagreed to share her experiences but did not discloseher name. Sinclair officials also declined to nameher. Her identity and her role have been independentlyverified by the Post-Dispatch. Her journey into radical activism was gradual, shesaid. It began when she was a teenager growing up nearthe East Coast. She started using only so-calledcruelty free beauty products, those which haven't beentested on animals. In college, she became avegetarian. A few years later, in 2002, she wasworking with primates at an animal sanctuary when shedecided to take a job with PETA. "I'm just a normal person who loves animals who feltthey weren't doing enough," she said during a recentphone interview. She quickly found her niche. She was uncomfortabletaking the normal route of helping with PETA's vocalprotests. She'd been there only two months but wantedto go undercover. Mary Beth Sweetland said she tried to talk her out ofit. Sweetland is PETA's director of research andinvestigations. She is the handler for the group'sundercover agents and knows how tough and lonely theassignments can be. She trains the spies on how to use the recordingequipment, how to conceal it, how to do their job andhopefully not break the law. She teaches them to bepatient and thorough. She asks the more experiencedinvestigators to give advice to the new charges. Shestays in almost daily contact with her team, what shecalls "my little army of the kind." Sweetland declined to give the exact number ofundercover agents employed by PETA. But her departmenthad a nearly $3 million annual budget last year,according to the nonprofit group's filings with theIRS. PETA is best known for its shocking antics andbillboards. Last November, members jumped on stage atthe Victoria's Secret fashion show in New York City toprotest the wearing of fur. The group is currentlygoing after Kentucky Fried Chicken with "KFC Cruelty"billboards in several cities. And PETA attracted lotsof attention — and outrage — with ads based on thepopular "Got Milk?" campaign suggesting, withoutevidence, that former New York Mayor Rudolph Giulianigot prostate cancer by drinking milk. The group, based in Norfolk, Va., thirsts forattention. By that measure, it is a success. It nowhas 750,000 supporters who donated nearly $17 millionto its operations last year. Celebrities have joinedits cause. This is a group with a self-describedradical agenda, summed up by its mission statement:"Animals are not ours to eat, wear, experiment on oruse for entertainment." Despite the attention paid to its inventive marketing,the real change sought by PETA comes from itsundercover work. "We are the heart and soul of thisorganization," Sweetland said. In just the past three years, the missions have led tothe prosecution of two men who were filmed beatinghogs on a hog farm and a federal inquiry intomistreatment of laboratory mice and rats at theUniversity of North Carolina. PETA is achieving broader changes, too. Last year, itconvinced the Safeway supermarket chain to force itsmeat suppliers to adopt more humane treatment ofanimals raised for slaughter. Recently, McDonald'sbowed to PETA pressure and agreed not to buy chickenfrom farmers who "de-beak" birds or keep them in cagessmaller than 72 square inches. Now, they're targeting the use of laboratory animals. Walking in the door Fresh off training, the young spy on PETA's payrollsaid she headed out to meet with a veteran PETAinvestigator in Kansas City. They spent a week holedup in a hotel there, where the veteran sharedpointers. One day they went to the circus and werepredictably upset. "Oh, the things people make animals do," the spyrecalled. "It's horrific." She then drove to Springfield and began job-hunting inearnest. She looked online, in newspapers and in thephone book. No luck. She punched up a governmentposting of registered research facilities, picked aname at random and called the number. It was Sinclair Research Center. They asked her to send her résumé. Everything on itwas true, even her name, she said. Two days later, shewas called for an interview. They liked her but wantedsomeone who had experience with computer spreadsheets.She ran out and bought books on how to use thesoftware. As with all her other expenses, PETA pickedup the tab. She went back two weeks later and showedoff her new skills. Bouchard, who runs the center, was impressed. "It'sthe type of person you look for," he said. She started her new job on May 6, 2002. Sinclair's history Sinclair Research Center is one of 35 animal researchlabs in Missouri, including seven in St. Louis, and 41in Illinois that are certified by the U.S. Departmentof Agriculture. Sinclair is a collection of white metal-framebuildings with green trim on 200 acres surrounded byfarmland in Callaway County. The construction may besimple, but the facility uses state-of-the-art energyrecovery and ventilation systems. Many of the buildings are shaped like double-longtrailers and contain two animal rooms separated by aprocedure area. The animal rooms feature metal cagesstacked two-high with a wide aisle down the middle.One room might be full of black Yucatan pigs for ahuman cardiovascular drug trial. Another might hold adozen tri-colored beagles eating a new pet foodformula. Bouchard's office is at the end of a second-floorhallway inside the center's only two-story building.The sound of barking dogs filters up from an animalroom below. The air is stuffy with the smell ofanimals. "The people we have are all animal lovers," Bouchardsaid during a recent visit. "You don't get intoresearch to get rich. You get into research becauseyou love animals." Bouchard took over the Sinclair operation from theUniversity of Missouri at Columbia in 1994. For almost30 years, the school ran the facility at a differentlocation in Columbia, where it had done groundbreakingwork in the use of animals to track human diseases. Bouchard was the attending veterinarian at Sinclairwhen the school considered closing it. Instead, hetook the center private. The new Sinclair Research Center started out with oneclient. By the time the spy walked in the front door,the center had many. And the transfer of operationsfrom the Columbia site to Callaway County was nearlycomplete. Bouchard, 40, is a big man with a boyish mop of lightbrown hair. He speaks with a thick French accent, alegacy of growing up on a farm in Rougemont, Canada,outside Montreal. His father was a police officer butalso kept livestock. Much of the work fell to his twosons. Before he was 4, Bouchard was helping his olderbrother feed 5,000 turkeys a day. He also had a petpig. Bouchard earned his doctorate of veterinary medicinein Montreal, before coming in 1990 to the Universityof Missouri for graduate studies in animalreproduction. A contract lab Sinclair is a contract animal laboratory. Just asother sectors have increasingly turned to outsourcing,companies that need to conduct animal tests sometimesuse outside labs. A common saying among workers at Sinclair is that "wemay not have the right to test on animals, but we dohave the need." Almost all research being done on breakthrough drugsto treat diseases like cancer, AIDS and Alzheimer'sdisease requires the use of lab animals, said Trull,president of the Foundation for Biomedical Research,an industry group in Washington representing medicalinstitutions and companies that use lab animals. Thefederal government also mandates animal tests for manyproducts that are to be used on humans. More than 1.1 million animals were used in researchnationwide in 2002, according to the USDA. About 60percent were rabbits, guinea pigs and hamsters, withthe rest made up of everything from dogs to primatesto pigs. The typical dog, cat or lamb at Sinclair is purchasedfrom a top-grade, regulated breeder, Bouchard said.Most animals spend their entire lives in the lab,going on and off different experiments, year afteryear. In animal research labs, the law of the land is thefederal Animal Welfare Act. It sets up minimumstandards of care and treatment. They includerequiring that dogs have the chance to exercise andthat all animals are given anesthesia orpain-relieving medication to minimize pain anddistress. USDA inspectors make surprise visits to the facilitieseach year. According to the USDA, Sinclair has norecord of wrongdoing. PETA sees its undercover actions as helping thegovernment do its job, Sweetland said. The USDA visitsfor a day, while the animal rights group stays formonths. "The USDA doesn't have the motivation wehave," she said. The tapes During the spy's tenure, there were several ongoingstudies: Iams contracted with Sinclair for tests usingmixed-breed dogs to evaluate the nutrition of dogfood. Nestle Purina Petcare was running cat litterstudies. Pet food studies also were conducted for MenuFoods, a Canadian private label pet food maker with aplant in Kansas. Sheep from Isto Technologies wereinvolved in studies of a new lab technique to growcartilage for humans. The spy shot hours of videotape inside Sinclair. Everynight, she'd go home to the apartment she rented inColumbia, watch the day's video and fill out adetailed report, which was e-mailed back to PETAheadquarters. The videotape — mostly of Iams, Menu Foods and Istostudy-related animals — was whittled down to snippetsof riveting scenes: * A beagle clawing maniacally at the metal bars of itscage; a dog circling wildly in its cage, anothercowering quietly in back; and a meowing cat pacingback and forth inside its cage. PETA claims these aresigns of distressed and bored animals. * A group of at least 10 beagles, slowly awakeningfrom anesthesia, lined up on the floor of an exam roomafter having their bone density measured by an X-raydensitometer. PETA claims such unsterile conditionsare unsafe. Bouchard said that the floor was clean and thatbeagles were placed close together to conserve bodyheat. * A dog, asleep from anesthesia, strapped on its backduring an X-ray. "When the dog is done, make surethey're breathing," an off-camera worker says, movinghis hand over the prone animal's stomach. "When yousee they've stopped breathing, give them (this)," theworker says, pantomiming a slap at the dog. * A pig in distress, convulsing on its side in a cage.A worker tells the spy that the pig almost died,perhaps from the position of a heart catheter, butthey managed to resuscitate the animal. * Employees discussing their work with sheep, sayingthat surgeries were rushed and that there wereproblems with the medical equipment. * Dogs walking gingerly on metal-slotted cage floors,the bars too narrow for their paws. In one scene, abeagle has its leg stuck in the slotted bottom. Thedog is obviously in pain and can't move. Another dogis later shown after being rescued from having its legcaught. As the animal holds its left hind leg off theground because of the pain, the camera zooms in on asevere red and green wound. Bouchard admits there were problems with the cagedesign, which has a slotted floor to collect animalfecal samples. But he said the problems were isolated.And any video of caged animals, no matter theircondition, plays on the emotions of the public, hesaid. "The bottom line is the animals had excellentveterinary care," Bouchard said. Another problem, Bouchard and Iams claim, is that thespy was put in charge of implementing an Iamsenrichment program — which should have providedexactly the type of care PETA criticizes them for notgiving. They allege that the spy stalled efforts toimprove the life of the dogs in order to supplyherself with dramatic video. "She came and all of asudden, we have more (problems) than we have in fiveyears," Bouchard said. The spy denied such accusations. Putting on the pressure The spy left her job on Feb. 19. She'd collectedenough evidence. It was time to go public. On March 25, PETA held a news conference in Dayton,Ohio, home to Iams, where the group introduced its newcampaign. They handed out press packets with stickersreading "Iams kills cats & dogs in 'nutritionalexperiments.'" While the link between Iams studies and dead animalsappears weak — dogs may have died while on the study,but the link between their deaths and the research isnot there — the PETA public relations machine madefull use of it. Iams said it had never before been targeted so heavilyby PETA. And PETA hasn't relented. The dominant imageon its Web site is the message "PETA to 'Pet' FoodIndustry: Lay Off the Animals," which links to morearticles and pictures featuring purportedly mistreatedanimals. There is growing concern within the pet food industrythat this is just the start of a broader campaign,said Iams spokesman Bryan Brown. "The signals are there that what they've done in thefast food industry," Brown said, referring to thechanges at McDonald's, "they're planning for us." The day after the news conference, a team from Iamsvisited Sinclair for a surprise inspection. They foundproblems with the air temperature and ventilation inthe cage rooms, a lack of resting boards for the dogsand inadequate socialization for the animals, Brownsaid. These items posed no serious health risks, Brown said,"but there were some gaps in following the Iamsresearch policy." Iams canceled its contract with Sinclair the next day.PETA's tactics also were successful in getting Iams toconduct inspections at all of the company's contractresearch labs and to adopt tougher lab requirements.Iams said it found no problems at its otherfacilities. Isto Technologies said in a statement that its work atSinclair is completed, but the company "is reviewingthe allegations made and takes this matter seriously."But Purina Petcare spokesman Keith Schopp said thecompany feels unfairly swept up by PETA's allegationsbecause officials have seen no evidence that animalsin its studies were mistreated. PETA research associate Peter Woods said Purina, whichdid not respond to PETA's letter alerting the companyto problems at Sinclair, "should be very concernedabout the people they do business with." "Effective" tactics While PETA's tactics are applauded in some circles,companies and institutions have tried unsuccessfullyfor years to stop these undercover operations, saidTrull with the Foundation for Biomedical Research. Theissue is addressed at professional conferences,warnings and advice are provided, but three monthslater they hear about another spy, she said. Trullblamed researchers for thinking that it just couldn'thappen to them. PETA has intimidated researchers who use lab animals,even driven some from the field, she said. And itappears the animal rights activists are winning thepublic relations battle, too, despite the medicaladvances made possible by animal testing, she said. "You've got to give them credit for being as effectiveas they've been," Trull conceded. One factor in PETA's recent success is the group'sincreasing willingness to set aside its long-term goalof abolishing all animal testing in favor of improvingthe treatment of lab animals in the meantime. "We hate it all," Sweetland said of animal testing,"but we're also very pragmatic." What the future holds PETA recently fired off a 104-page complaint to theUSDA, alleging dozens of instances of failure toprovide adequate care for animals at Sinclair. Theagency is reviewing the claims, a spokesman said. Bouchard said he's considering legal action againstPETA for its use of an undercover investigator. Hepointed to a little-known state law that makes itillegal to access "an animal facility by falsepretense for the purpose of performing acts notauthorized by the facility." This year, some legislators tried to add to the law bymaking it illegal to photograph "any aspect of ananimal facility." That measure, derided by otherlawmakers as the "puppy mill protection act," failed. Bouchard plans to keep operating Sinclair and woo backsome of his lost clients. He has installed bettercages with new flooring for dogs so they won't gettheir feet caught. He's ordered new cat cages,increasing their size to 9 square feet. But Bouchard said the one thing he's lost that can'tbe regained is trust. He is suspicious of everyonenow. He is dreading when the time comes to hire a newemployee, fearful that it will be another undercoverinvestigator. The spy said she is sorry if her former co-workerswere hurt by her actions. But for her, the deceit wasnecessary. "How else is there to know what goes onbehind closed doors?" she asked. Going undercover "isthe only way." Sweetland, who guided the young spy, said PETA willkeep fighting. "They will never succeed in keeping us out of thelabs," Sweetland said. "We will always be doing this."Now, the spy who made it inside Sinclair is back onthe road, traveling somewhere in the South. She'slooking to get behind closed doors once again. She's ready for her next mission.

Thursday, August 24, 2006

medical stuff

By Randy DotingaHealthDay Reporter 39 minutes ago
THURSDAY, Aug. 24 (HealthDay News) -- New research in mice points to a possible treatment for
Alzheimer's disease" name=c1> SEARCHNews News Photos Images Web' name=c3> Alzheimer's disease, one that repairs brain cells so they can rid themselves of the amyloid beta proteins that are suspected of contributing to the disease.
By tinkering with an enzyme in the brains of mice afflicted with the rough equivalent of Alzheimer's in humans, scientists were able to improve the rodents' memories.
There's no way to know if the approach will work in humans, but researchers are hopeful. In essence, "we were able to restart -- or make more efficient -- the garbage disposal function of the cell," said study co-investigator Dr. Michael Shelanski, director of the Alzheimer's Research Center at Columbia University.
Despite intensive research, Alzheimer's disease remains very difficult to treat and affects about 4.5 million Americans, a number that is expected to soar in the coming decades as the population ages. Some drugs are available, but their effectiveness is limited, Shelanski said.
According to Shelanski, the new research expands on previous findings that suggested a shortage of an enzyme in the brain may be connected to Alzheimer's. The enzyme, known as Uch-L1, appears to be crucial to a cell's ability to get rid of malformed proteins and maintain memory.
"It has been widely assumed in Alzheimer's disease that a lot of the problem comes from the fact that proteins within the cell do not fold correctly, and therefore don't function correctly," Shelanski said. "The cells' garbage disposal tries to get rid of them."
Researchers engineered mice to suffer from a kind of rodent Alzheimer's disease. Then they boosted the level of the enzyme in the mice to see what would happen.
The treated mice were able to remember to avoid parts of a cage floor where they had earlier been exposed to a mild stimulus. The other mice forgot the places to avoid, the study found.
The study findings appear Thursday on the Web site of the journal Cell.
"We were able to greatly improve function in mice that had (the equivalent of) Alzheimer's disease for as long as a year," Shelanski said. That could reflect changes that would happen in a human who had Alzheimer's for many years, he added.
Will it work in humans? No one knows. One downside is that the treatment must be injected, not taken as a pill by mouth. And it might not be safe in people.
"This is hope, not proof, that even people with established Alzheimer's disease might be able to get some recovery from a therapy that works along these lines," Shelanski said.
Another Alzheimer's specialist called the study "interesting, exciting, and important."
The research points to "a previously understudied area of investigation that may be useful for developing drugs for Alzheimer's disease," said Dr. Sam Gandy, director of the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia.
He added that the new research relies upon the most commonly accepted theory about what causes Alzheimer's, although it still remains to be proven.
Unfortunately, he said, it will take years to develop a drug for people.

Wednesday, August 23, 2006

Animal stuff

By Jeanna BrynerSpecial to LiveScienceposted: 23 August 200612:05 am ET

Whether it's a blowout argument or a dinner-table disagreement, a spat with your lover can be trying. Humans have of course devised ways of making up, including tight hugs and the customary apology flowers.
Killer whales have their own tricks for mending relations, a new study finds. Rather than a bouquet, however, they might opt for an intimate swim.
Studies have shown that chimpanzees kiss and hug after a dispute, and other primates such as bonobos resort to sexual activity to resolve conflicts. Until now, reconciliatory behavior had not been shown in any marine mammal.
For the past five years, Michael Noonan, a psychologist and specialist in animal behavior at Canisius College in Buffalo, New York, has been studying the captive killer whales at the theme park Marineland of Canada in Niagara Falls, Ontario. To learn more about orca social behavior, Noonan videotaped a group of captive killer whales for a total of 2,800 hours.
"Nearly all social animals occasionally squabble," Noonan said.
He noted 21 disagreements, many of which involved complicated interactions between several whales. Most notably, the video revealed eight unambiguous quarrels between one pair—a mother and a father. The disputes entailed aggressive chasing, Noonan said.
Orcas, the largest members of the dolphin family, can reach swimming speeds at sea of 30 miles per hour (50 kilometers per hour) for short stints.
After the mother chased the father for several minutes, each zipped away to separate aquatic quarters to cool off for about 10 minutes. Then, the mates smoothed over their clash with side-by-side swimming, called echelon swimming [image].
"In eight out of eight instances, the animals engaged in a pro-social, affiliative behavior shortly after the period of tension," Noonan told LiveScience. "The pro-social behavior was echelon swimming."
Animal behavior scientists have known that orcas take part in echelon swimming as a form of routine social bonding. "That these two [killer whales] did it so consistently after periods of tension is the new discovery," Noonan said.
The research was presented at the Animal Behavior Society conference earlier this month in Salt Lake City.
"It shows yet another way in which cetaceans have converged with primates, Noonan said. Other similarities: large brains, long lives and social complexity.
But Noonan is still trying to elucidate some secrets held by these black-and-white mammals. For instance, what triggered the domestic squabbles? "We are working on that," he said.